Forum

«Continuous Flow Techniques for Fine Chemical Manufacturing»

While commodity chemicals are usually produced in thoroughly optimized continuous production plants, pharmaceuticals are typically synthesized in general-purpose batch or semi-batch reactors.

While commodity chemicals are usually produced in thoroughly optimized continuous production plants, pharmaceuticals are typically synthesized in general-purpose batch or semi-batch reactors. Despite their prevalence in the pharmaceutical industry, batch-type reactors have some well-recognized limitations.
Continuous flow technology provides an appealing alternative to batch reactors and offer the potential to reduce production costs, increase product consistency and strengthen process robustness. Moreover, process development and scale-up would be facilitated by the adoption of continuous flow reactors in the initial stages of molecule discovery and synthesis. However, the selection of the optimal reactor technology in these applications is not trivial and requires a thorough understanding of the reaction kinetics, flow patterns, and phases.
In this talk the design and scale up of continuous flow plate type reactors will be discussed and the concept of mini-monoplant technology will be introduced.[1] Recent examples will be given to demonstrate the versatility of continuous processing in the field of API manufacturing. The focus will be on exothermic
reactions and reaction with reactive gases such as ozone and oxygen.[2]

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Speakers (1)

Bernhard Gutmann, Lonza

Bernhard Gutmann, Lonza

Chemist R&D