Mittwoch, 20. Oktober 2021 | 17:15 - 18:00

Forum

Programmpunkt

«Harnessing biocatalysis for sustainable synthetic...»

Title:«Harnessing biocatalysis for sustainable synthetic processes» Prof.Francesca Paradisi, Department of Chemistry, Biochemistry and Pharmaceutical Sciences University of Bern, Freiestrasse 3 CH-3012 Bern, Switzerland, francesca.paradisi@unibe.ch

Flow chemistry has allowed many industrial processes to be carried out in continuous mode, with higher efficiency and automation. Biocatalysis has caught up with this technique and several examples have been reported in the literature in the last decade. However, the complexity of multi-enzymatic processes in the absence of cellular regulation, has limited their applications to some chemo-enzymatic synthesis, and just a few fully enzymatic processes have been implemented. Among others, the cofactor requirements of redox enzymes, the stability of the biocatalyst, and efficiency of the biotransformations, must be thoroughly optimized. Furthermore, the mobile phase is rarely recovered, minimizing the real environmental impact of enzymatic reactions. Here the steady evolution of flow biocatalysis in our laboratory will be presented,
[1,2] moving towards systems of increasing complexity with combinations of several enzymes, which resulted in a breakthrough in the design and implementation of an ultra-efficient zero-waste and closed-loop process with unprecedented atom efficiency and automation (Figure 1).[3]

With this technology, we successfully achieved the synthesis of metabolic intermediates of biogenic amines, such as hydroxytyrosol, tryptophol, histaminol, for which chemical synthesis is hampered by very low yields.[4] Additional examples will show how we have designed efficient biocatalytic cascades to synthesize a range of valuable chemicals.[5–7]

References:  
[1]           M. Planchestainer, M. L. Contente, J. Cassidy, F. Molinari, L. Tamborini, F. Paradisi, Green Chem. 2017, 19, 372, DOI: 10.1039/C6GC01780K.
[2]           M. L. Contente, F. Dall’Oglio, L. Tamborini, F. Molinari, F. Paradisi, ChemCatChem 2017, 9, 3843, DOI: 10.1002/cctc.201701147.
[3]           M. L. Contente, F. Paradisi, Nat. Catal. 2018, 1, 452, DOI: 10.1038/s41929-018-0082-9.
[4]           B. R. Lichman, E. D. Lamming, T. Pesnot, J. M. Smith, H. C. Hailes, J. M. Ward, Green Chem. 2015, 17, 852, DOI: 10.1039/C4GC02325K.
[5]           D. Roura Padrosa, V. De Vitis, M. Contente, F. Molinari, F. Paradisi, Catalysts 2019, 9, 232, DOI: 10.3390/catal9030232.
[6]           M. L. Contente, S. Farris, L. Tamborini, F. Molinari, F. Paradisi, Green Chem. 2019, 21, 3263, DOI: 10.1039/c9gc01374a.
[7]           M. Romero-Fernandez, F. Paradisi, Green Chem. 2021, 23, 4594, DOI: 10.1039/d1gc01095f.

 

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